ABCB11 and cholestasis: The current mechanistic understanding of iDILI includes activation of the adaptive and innate immune response in part by danger-associated molecular pattern molecules (DAMPs) and drug/metabolite exposure and collectively leading to (1) reactive metabolite accumulation and cholestasis, (2) mitochondrial dysfunction, (3) bile salt export pump (BSEP) inhibition, and (4) lysosomal impairment (Figure 1).