Finally, ABCB5+ MSCs are also capable of secreting type VII collagen [30], which raises the possibility that repeatedly grafted allogeneic ABCB5+ MSCs could additionally contribute to skin integrity improvements also through the provision of functional type VII collagen, lack of which is the primary cause of skin fragility in RDEB. Here, ABCB5 is linked to recessive dystrophic epidermolysis bullosa.