Previously published results showed that the biomechanical properties in neuroblastoma SH-SY5Y cells subjected to OGD were associated with the remodeling of actin filaments, as well as cofilin-based regulation and impaired metabolic activity of cells, showing the importance of nanomechanics in research on ischaemia-related pathological processes such as stroke [63]. Here, CFL1 is linked to stroke disorder.