The family of bromodomain (BRD) and extra-terminal domain (BET) proteins comprises four members—BRD2, BRD3, BRD4, and bromodomain testis-specific protein (BRDT)—and plays a critical role in the development and pathogenesis of cardiovascular diseases (CVDs), including heart failure, atherosclerosis, pulmonary arterial hypertension, and renal ischemia-reperfusion injury [1,2,3,4,5]. Here, BRDT is linked to heart failure.