Leiomodins are members of the tropomodulin superfamily that bind the pointed end of actin thin filaments, including smooth muscle leiomodin-1 (Lmod1), cardiac predominant leiomodin-2 (Lmod2), and muscle-predominant leiomodin-3 (Lmod3), which has recently been implicated in congenital nemaline myopathy. This evidence concerns the gene LMOD1 and nemaline myopathy.