LMOD2 and nemaline myopathy: Leiomodins are members of the tropomodulin superfamily that bind the pointed end of actin thin filaments, including smooth muscle leiomodin-1 (Lmod1), cardiac predominant leiomodin-2 (Lmod2), and muscle-predominant leiomodin-3 (Lmod3), which has recently been implicated in congenital nemaline myopathy.