In a small-scale study, spatial transcriptomics allowed for the identification of the dysregulation of GRM3 (coding for Glutamate metabotropic receptor 3) and USP47 (coding for Ubiquitin Specific Peptidase 47) genes in the cerebellum of an ALS-C9orf72 patient, a finding which was corroborated in different brain areas of a larger cohort of patients, including ALS-C9orf72, ALS-SOD1, and sALS cases, using an in situ hybridization technique [49]. This evidence concerns the gene GRM3 and amyotrophic lateral sclerosis.