GRN and frontotemporal dementia: In particular, a recent study, aiming at investigating the transcriptome of non-neuronal cells in FTD patients carrying GRN mutations (FTLD-GRN), revealed the appearance of a disease-associated astrocyte subpopulation characterized by the expression of WDR49 (WD repeat domain 49) and the perturbation of several grey matter astrocyte pathways, including signaling to neurons, other parenchymal cells, and endothelial cells [39].