There is evidence that TASL involves in regulating the endolysosome pH of immune cells such as dendritic cells and monocytes [41], while SLC15A4 (a proton-coupled amino acid transporter bound to TASL) is an important metabolic regulatory molecule [23], and the TLR pathway directly regulates metabolism and affects the behavior and function of tumors such as melanoma and breast cancer [42], which may provide strong evidence for our findings. This evidence concerns the gene SLC15A4 and melanoma.