Interestingly, a variety of classical metabolic pathways were extensively downregulated in the high TASL expression group, including oxidative phosphorylation, glutathione metabolism, etc. It is reasonable that oxidative phosphorylation is negatively correlated with immune pathways in cancer since reduced tumor immune activity is often accompanied by metabolic reprogramming from oxidative phosphorylation to glycolysis [28, 40]. The gene discussed is TASL; the disease is cancer.