Considering the different relationship between TASL expression and survival of LGG, LUAD, and SKCM patients, the results of the analysis suggested that TASL may differentially affect the prognosis of the three cancer types by mediating an immunosuppressive microenvironment in “cold” tumor LGG and an immunostimulatory microenvironment in “hot” tumors LUAD and SKCM. The gene discussed is TASL; the disease is cancer.