Further analysis revealed that TASL may affect the level of tumor immune infiltration mainly by mediating TILs and TAMs, and TASL may differentially affect the prognosis of the three cancer types by mediating the immunosuppressive microenvironment in immune “cold” tumor LGG and the immunostimulatory microenvironment in immune “hot” tumors LUAD and SKCM. Here, TASL is linked to cancer.