In this study, we identified SE-associated genes by integrating cell-specific SEs with RNA-seq data and found six genes (CAPG, CD207, GPR132, SLC7A11, HIPK3 and FCER1G) that are correlated with poor prognosis in acute myeloid leukemia (AML) patients according to the TCGA-LAML database. The gene discussed is HIPK3; the disease is acute myeloid leukemia.