Indeed, the cell-cell interaction analysis revealed that after V-Navo@gel treatment there were more communications between cancer cells and different clusters of T cells through CCL2/CCR2, CXCL10/CXCR3 and CXCL11/CXCR3 pairs, which might contribute to the increased intratumoral infiltration of T cells induced by V-Navo@gel. Here, CCL2 is linked to cancer.