The final multivariate logistic regression results showed that BMI > 25 (OR = 1.413, 95% CI 1.053–2.421, P = 0.007 vs < 25), Leukocytes (OR = 1.217, 95% CI 1.162–1.303, P = 0.001 per 109), INR (OR = 1.244, 95% CI 1.079–1.462, P = 0.013 vs per 1), HBP (OR = 1.070, 95% CI 1.044–1.098, P < 0.001 vs per 1 ng), CRP (OR = 1.010, 95% CI 1.004–1.016, P = 0.001 vs per 1 mg) and PCT (OR = 1.030, 95% CI 1.007–1.053, P < 0.001 vs per 1 ng) were significantly associated with severe acute pancreatitis (Table 3). The gene discussed is CRP; the disease is acute pancreatitis.