MKI67 and neoplasm: The higher IHC staining intensity of GFP and cleaved caspase3 and lower Ki-67 signal in the M1-N3E2M group than in the M1-GFP group indicated that M1-N3E2M replicated more robustly in tumor tissues, thus inhibiting the proliferation of tumor cells and promoting their apoptosis (Fig. 3c).