Indeed, a direct correlation of nuclear SREBF1 & H2A-K130ac with the disease progression to later stage in prostate cancer patients (Fig. 7), and recent report of elevated expression of KAT2A/GCN5 in patients with high-grade prostate cancer or recurrence following radical prostatectomy45, endorse the importance of this signaling pathway. Here, KAT2A is linked to Familial prostate cancer.