Numerous studies have demonstrated the critical roles that circRNAs play in cancer signaling pathways, including the PI3K/Akt, JAK/STAT, GEF-H1/RhoA, Wnt/-Catenin, and TGF-/Smad pathways, by upregulating oncogene expression, downregulating tumor suppressor genes, and/or downregulating downstream proteins [82–86]. Here, ARHGEF2 is linked to cancer.