SART3 and cancer: KEGG pathway and Gene Ontology (Biological pathway; GO_BP) enrichment analysis for the 1000 most-divergent genes between control and homozygous iPSCs (based on FDR, Supplementary Data 2) using DAVID (Database for Annotation, Visualization and Integrated Discovery)28 highlighted pathways and processes in which SART3 has previously been implicated, such as cancer signalling29 and stem cell pluripotency30 (Fig. 6b).