In order to confirm these results in a more stressed condition, which could reproduce the clinical situation more reliably, the same experiment of co-culture with lymphoma cells was also performed at suboptimal conditions of decreased E:T ratio (from 1:1 to 1:80), to further evaluate whether the IFNγ neutralization could impact the cytotoxic activity of CAR.CD19-T cells. Here, IFNG is linked to lymphoma.