Moreover, we implanted these cells into randomized NOD/SCID mice by tail vein injection and found that IGFBP1 depletion dramatically inhibited the metastasis of tumor cells rescued with rSOD2 WT, while failed to do so in the cells rescued with rSOD2 S27A, as determined by H&E staining of dissected lung tissues (Figure 7C). Here, IGFBP1 is linked to neoplasm.