IGFBP1 and neoplasm: To define the relationship between the expression of IGFBP1 and the survival duration of lung cancer patients, we performed survival analysis of lung adenocarcinoma patients by using UALCAN database (http://ualcan.path.uab.edu), which showed that the patients whose tumors had high expression of IGFBP1 (124 cases) exhibited shorter survival time than those with lower expression of IGFBP1 (378 cases) in the tumor cells (Figure S1F, Supporting Information).