Insulin‐like growth factor‐binding protein 1 (IGFBP1) is a member of the family of secreted proteins that specifically binds and modulates the mitogenic and metabolic functions of insulin‐like growth factor (IGF)‐1 and IGF‐2.[14] In this study, we carried out RNA‐sequencing analysis in tumor cells during confined migration and found that IGFBP1 is upregulated in confined cells and secreted IGFBP1 sustains cell survival during confined migration by regulating SOD2 phosphorylation and activity, thereby promoting tumor metastasis. The gene discussed is IGF2; the disease is neoplasm.