MYC and infection: When we further investigated whether this impact was an HIV-1-integration site–specific phenomenon or an HIV-1-infection–specific phenomenon, we found that our observed differences in Hi-C and H3K27ac HiChIP, when comparing infected and uninfected cells, were present in all HIV-1-infected lines regardless of whether those cells contained an integration site at that location (Fig. 4G–L) or were at model loci on separate chromosomes (for BACH2, see Supplemental Fig. S6A–F; for MYC, see Supplemental Fig. S6G–L).