Immune cells, according to their exact subtype and their activation status, whether they are exhausted, effector T cells or effector memory cells, have a different impact on tumour progression (for example, Th1, Th2, Th9, Th17, Th22, or Treg for CD4+ T cells; M0, M1, M2 for macrophages; Tc1, Tc2, Tc9, Tc17, Tc22 for CD8+ T cells; cDC1, cDC2, pDc, moDc, iDc, Langerhans cells for dendritic cells; or N1 and N2 for neutrophils). The gene discussed is CD4; the disease is neoplasm.