Approximately 41%of synaptic proteins have been identified as S-palmitoylated,including APP, BACE1, and Huntingtin (HTT), which are involved inAlzheimer’s and Huntington’s disease (HD).14,15 To better understand the role of S-palmitoylationin the CNS in health and disease, it is crucial to study how S-palmitoylation is regulated in neurons. Here, APP is linked to Huntington disease.