The results of the univariate analysis were confirmed by multivariable MR, which showed no causal effect of adiponectin on RA in both Europeans (OR = 0.97; 95% CI = 0.77–1.21; p = 0.78) and East Asians (OR = 0.98; 95% CI = 0.66–1.46; p = 0.93. Here, ADIPOQ is linked to rheumatoid arthritis.