Studies were conducted on “the prevalence of cryptococcal infection among HIV-persons with a CD4 cell count of less than 100 cells/μL” however, the clinical characteristics of PLHIV, with the progression to CM proportional to elevated CD4 cell counts (101–200 cells/μL), would contribute discernment into the role of the immune response to the pathogenesis of CM [9, 11, 13, 14]. The gene discussed is CD4; the disease is cryptococcosis.