ANGPTL8 and triple-A syndrome: In addition, ANGPTL8 knockout significantly reduced the incidence of AAA (80% vs. 40%, P<0.05; Figure 2C) and maximal diameter of the abdominal aorta (1.5 ± 0.2 vs. 3.9 ± 0.1 mm, P<0.05) following infusion of Ang II compared with saline (Figure 2E,F).