PIK3CA and breast cancer: Finally, network analysis of the 35 most-upregulated genes in the SHP2 inhibition group compared to the Vehicle group using cBioPortal (https://www.cbioportal.org/) and the breast cancer METABRIC dataset showed convergence to Src Homology 2 Domain-Containing 1 (SHC1), PIK3CA and AKT3 (Fig. 2F, Fig S3G).