Nonetheless, IL-4–producing and GVHD-regulating iNKT cells after nonmyeloablative preparation (15) appeared redundant (14), and mechanisms linking specific cell types of the recipient to Th2- and TGF-β–mediated regulation of GVHD has been unknown in our model of myeloablative BMT. The gene discussed is IL4; the disease is graft versus host disease.