TGFB1 and chronic pancreatitis: In Figure 5D, SNHG11, which was up-regulated in plasma of chronic pancreatitis (CP) patients and TGF-β1-treated pancreatic stellate cells (PSCs) [32], was adaptively decreased after short-term HFD feeding as a negative gene and increased after long-term HFD feeding with the destruction of the adaptively protective mechanism.