C1QTNF3 and chronic kidney disease: With the progression of CKD, the level of serum CTRP3 increased gradually (H = 14.827, p = .001), and the level of 25(OH)D3 decreased gradually (H = 40.834, p < .001); in contrast, the level of FGF23 (H = 3.904, p = .142) did not change significantly (Figure 2).