Consistent with a potential role for PLN as a AF-contributing gene, three large independent GWAS (Christophersen et al., 2017; Nielsen et al., 2018a; Roselli et al., 2018) have identified SNPs in the vicinity of the PLN gene locus in patients with AF (Christophersen et al., 2017; Nielsen et al., 2018a; Roselli et al., 2018), although the functional significance of such variants is unknown. The gene discussed is PLN; the disease is atrial fibrillation.