GJC3 and central nervous system cancer: In M_SC3, Gjc3 expression has been shown to increase in microglia associated with gliomas and near trauma sites (Szulzewsky, 2015), and transcriptional regulator Lmo4 is a coactivator in the TGFβ signaling pathway (Lu et al., 2006), a critical pathway the regulates microglia adaptation (Zöller et al., 2018).