Finally in M_SC4, increased expression of Ncf1/p47phox has been reported in phagocytic microglia (Haslund-Vinding et al., 2017) and upregulation of Tyrobp and Trem2 (a M_SC4 top marker gene) are known markers for DAMs, Alzheimer’s disease-associated microglia with phagocytic activity (Keren-Shaul et al., 2017). Here, TREM2 is linked to early-onset autosomal dominant Alzheimer disease.