However, in studying the effect of the SIRT1-FoxO1-Rab7 axis on the autophagy and malignant biological behavior of GC cells under GD conditions, we only used siRNA interference technology to reduce SIRT1, FoxO1 and Rab7 proteins in GC cells with high SIRT1 expression and did not treat the cells with SIRT1, FoxO1 or Rab7 inhibitors to verify their effects on the cells. The gene discussed is FOXO1; the disease is gastric cancer.