SIRT1 and gastric cancer: Although our results showed that GD alone could slightly inhibit the migration and invasion of GC SGC-7901 cells and mildly promote cell apoptosis, the decrease in SIRT1 expression inhibited the intracellular autophagy activity under GD condition, significantly reduced the tolerance of GC cells to GD, enhanced the inhibition of GC cell proliferation, migration, invasion and apoptosis by GD.