Jabati et al. conducted a baseline analysis of circulating biomarkers in a group of patients with AF prior to ablation and found that different prothrombotic, inflammatory, and collagen turnover biomarkers (PAI-1, CD40L, nucleosomes, CRP, procollagen III N-terminal propeptide, and procollagen III C-terminal propeptide) are elevated in AF. Here, SERPINE1 is linked to atrial fibrillation.