CAT and myelofibrosis: Moreover, TGF‐β and ROS interact not only in their self-synthesis, but also in the downregulation of antioxidant enzymes such as glutaredoxin, catalase, superoxide dismutase, and GPX (71), the latter which has been proposed to alleviate the activation of the TGF‐β/SMAD signaling pathway, which is involved in the progression of myelofibrosis (72).