PRKG1 and preeclampsia: Figure 6C shows that SNP- or Bay 41-2272-decreased amplitude on the baseline vessel tone was less in PEPV than that of the CPV. The sGC inhibitor (ODQ) significantly blocked SNP-mediated reduction on the baseline tension in CPV and PEPV. Although there was no significant difference in GUCY1A3 and PRKG1 protein expressions as well as higher GUCY1B3 protein expression, the sGC activity in preeclampsia placenta vessels was obviously declined (Figure 6D).