In this prospective study, we evaluated the clinical biomarkers (NLR, LDH, ferritin, CRP, procalcitonin, and D-dimer) during the acute phase of SAR-CoV-2 infection which will help to predict long-term SARS-CoV-2-specific IgG antibody response as late as 6 months following natural infection. The gene discussed is CRP; the disease is infection.