Supplementary Figure S1A presents an enhanced volcano map that displays the differential gene expression between CS1 and CS2, with 19,168 total differentially expressed genes. In addition, the GO analysis demonstrated that DEGs between ccRCC subtypes were annotated in receptor antagonist, receptor inhibitor, peptidase inhibitor, peptidase regulator, and enzyme inhibitor activity in biological process (Supplementary Figure S1B). The gene discussed is LAP3; the disease is nonpapillary renal cell carcinoma.