The MPM II utilizes data on health status on admission, preexisting metastatic neoplasm or cirrhosis; acute diagnosis of infection, coma, and intracranial mass effect; physiological covariates of Cr levels, urine output, and partial pressure of oxygen; laboratory findings of prothrombin time; and additional factors such as mechanical ventilation and use of vasoactive drugs, to determine the outcome [42]. Here, F2 is linked to metastatic neoplasm.