Genetic or pharmacologic reduction of NLRP3 activity attenuates hypertension in numerous animal models of hypertension (Wang et al., 2012; Gong et al., 2016; Krishnan et al., 2016; Krishnan et al., 2019; Pitzer et al., 2020; Li et al., 2022). The gene discussed is NLRP3; the disease is hypertensive disorder.