TPO and adult T-cell leukemia/lymphoma: showed that patients with ATLL and asymptomatic HTLV-1 carriers had significantly more anti-TPO (anti-thyroperoxidase) and anti-thyroglobulin (anti-TG) antibodies than the control group of seronegative patients, with an expected female predominance in the seronegative group (Akamine et al., 1996).