TSC2 and autism: Similarly, mTOR/4E-BP hyperactivation in Tsc2+/− mice is accompanied by a wide range of rapamycin-sensitive phenotypes: decreased hippocampal metabotropic glutamate receptor long-term depression (mGluR-LTD) (Auerbach et al., 2011), deficits in learning and memory (Ehninger et al., 2008) and autism-related behaviors such as changes in social interaction (Sato et al., 2012).