SNAI1 and Familial prostate cancer: In another study using prostate cancer epithelial cells, PKD1 was shown to inhibit EMT by phosphorylating the transcription factor SNAI1, which promotes the repression of the adhesion molecule E-cadherin to regulate EMT, directly at Ser11, leading to its binding to 14-3-3 proteins and subsequent nuclear export of SNAI1.