For example, PI4KIIIβ, which generates phosphatidylinositol-4-phosphate (PI4P) and vesicle carriers at the TGN and whose activity is stabilized by PKD-mediated phosphorylation (Hausser et al., 2005; 2006), is overexpressed in breast cancer tumors (Morrow et al., 2014). Here, PRKD1 is linked to breast cancer.