By promoting αvβ3 recycling, rabaptin-5 phosphorylation negatively affects invasion in fibronectin-rich matrices, whereas in fibronectin-deficient microenvironments, where invasion depends on αvβ3 rather than α5β1, rabaptin-5 phosphorylation is a strong driver of tumor cell invasion (Christoforides et al., 2012). This evidence concerns the gene RABEP1 and neoplasm.