However, multiple groups have demonstrated that deletion of IFN-γ or its receptor does not impact spontaneous diabetes development in the NOD mouse (Hultgren et al., 1996; Kanagawa et al., 2000; Serreze et al., 2000; Carrero et al., 2018; Jhala et al., 2022). The gene discussed is IFNG; the disease is diabetes mellitus.