Blocking CXCL10 reduces diabetes (Christen et al., 2003; Christen and Kimmel, 2020) and splenocytes from diabetic NOD mice were less efficient at transferring diabetes into IFN-γ or IFNGR-deficient NOD mice due to impaired homing of T cells into islets (Savinov et al., 2001). The gene discussed is IFNGR1; the disease is diabetes mellitus.