While a potential involvement of VprBP-mediated EZH2 phosphorylation in melanomagenesis was not explored in the current study, stable depletion and inhibition of VprBP in melanoma cells expressing low levels of EZH2 still generated a substantial increase in melanomagenic gene transcription and cell growth rates (data not shown), lending support to the notion that the pro-melanomagenic activity of VprBP is mainly through H2AT120p at target genes. Here, EZH2 is linked to melanoma.