On the other hand, VprBP kinase dead mutant failed to recover the growth capacity of VprBP-depleted G361 and MeWo cells (Fig. 2a and Additional file 3: Fig. S3a), underscoring the notion that VprBP-mediated H2AT120p is critical for VprBP function in promoting melanoma cell growth. Here, DCAF1 is linked to melanoma.