CHMP5 and viral infectious disease: Having demonstrated the presence of high-titers of anti-Spike antibodies with OMVs incorporating all three-fusion proteins, we next asked whether such antibodies could also neutralize virus infection in vitro. To this end, neutralization was assessed through a pseudovirus assay using a GFP-encoding lentiviral vector based on SIV and pseudotyped with the SARS-CoV-2 Spike protein.