In malignant peripheral nerve sheath tumors (MPNST) EYA4 is over-expressed (9), whilst it is down-regulated in esophageal adenocarcinoma (10, 11), hepatocellular carcinoma (12), lung cancer (13) and colorectal cancer (14), where the EYA4 gene promoter has been found to be hypermethylated. This evidence concerns the gene EYA4 and esophageal adenocarcinoma.