EYA4 and lung cancer: In malignant peripheral nerve sheath tumors (MPNST) EYA4 is over-expressed (9), whilst it is down-regulated in esophageal adenocarcinoma (10, 11), hepatocellular carcinoma (12), lung cancer (13) and colorectal cancer (14), where the EYA4 gene promoter has been found to be hypermethylated.