MYC and neoplasm: On the other hand, predictive biomarkers derived from transcriptomics data include tumor oncogene expression signatures such as genes related to MYC (8), WNT/ß-catenin (9,10), or RAS (11) signaling, or gene expression profiles within the tumor immune microenvironment (TIME) such as interferon-γ (IFN-γ) responsive genes (12), chemokines (13,14), major histocompatibility complex (MHC) class I and II (15), and cytotoxic T-cell and T-cell effector (16,17) gene expression markers that have been reported to be predictive of ICI response in metastatic melanoma.