AKT isoforms exert different effects on the survival of PC cell lines [32, 38, 39, 67, 68], and importantly, Chin et al. [38] showed that PTEN-deficient human LNCaP cells show a greater reliance on AKT2 for maintenance and survival in anchorage-independent growth conditions. This evidence concerns the gene AKT1 and pachyonychia congenita.