AKAP12 and prostate intraepithelial neoplasia: Indeed, Akap12−/−;RbPE:−/− transgenic male mice in the C57BL/6 background developed high-grade prostatic intraepithelial neoplasias (HG-PIN), and consistent with AKAP12’s role as a metastasis-suppressor [10], these mice exhibited dissemination to local lymph nodes of indolent, transitional PC cells that express both basal and luminal epithelial markers [3].