INS and diabetes mellitus: A gene set enrichment analysis showed these “top 50 genes” to be over-represented in 38 gene sets (at false discovery rate q-value < 0.01; Supplementary Table 13), 25 of which were defined using terms related to metabolic phenotypes of T2D (e.g., ‘diabetes’, ‘hyperglycemia’, ‘overweight’, ‘waist’, ‘insulin’, ‘c-peptide’, Methods).