Like HNF1A, both GCK (OR 7.69, P = 5.0×10− 5) and RFX6 (OR 47.9, P = 3.7×10− 4) had ProDiGY associations with large effect sizes, 3.1-fold and 22-fold higher (respectively) than their association effect sizes in adult-onset T2D (AMP-T2D-GENES). The gene discussed is HNF1A; the disease is type 2 diabetes mellitus.