While we cannot conclude that the cells identified in our analysis represent bona fide CAFs based solely on in silico results, P-FB cells express several CAF-specific gene markers (PDGFRA, FAP, FN1, COL1A1) and transcription factors (NR2F1) (Wu et al. 2022), which warrants further investigation of their identity and pro-tumorigenic roles in GBM. This evidence concerns the gene COL1A1 and glioblastoma.