CXCL12 and neoplasm: CellChat predicted active chemoattractant signaling from P-FB cells to macrophages via chemokines CCL2, CXCL1, CXCL2, CXCL12, CSF1, and matricellular protein periostin (POSTN), which are known to induce chemotaxis and alternative polarization of tumor-supporting M2-like myeloid cells (Figure 3D–F) (Turley, Cremasco, and Astarita 2015; Sánchez-Martín et al. 2011; Shi et al. 2018; Zhou et al. 2015; Stafford et al. 2016; Flores-Toro et al. 2020).