People with non-O blood group have higher levels of von-Willebrand factor and LDL-cholesterol, both of which may potentially contribute to VTE.[49] The mechanism by which blood group affects cancer risk is unknown, although it is hypothesised that ABO antibodies interact with aberrant glycoproteins expressed on pancreatic tumour cells.[52] It is also plausible that the association between VTE and pancreatic cancer is mediated by ABO blood group. Here, VWF is linked to familial pancreatic carcinoma.