To study the association of rare variants in the new nominated genes, we performed burden analyses in two cohorts (Accelerating Medicines Partnership - Parkinson Disease and UKBB) with a total sample size PD patients n=2,943 and controls n=18,486.<h4>Results</h4>We identified a novel locus associated with PD among <i>MAPT</i> H1/H1 carriers near <i>EMP1</i> (rs56312722, OR=0.88, 95%CI= 0.84-0.92, p= 1.80E-08), and a novel locus associated with PD among <i>MAPT</i> H2 carriers near <i>VANGL1</i> (rs11590278, OR=1.69 95%CI=1.40-2.03, p=2.72E-08). Here, VANGL1 is linked to Parkinson disease.