VWF and Thrombocytosis: According to our data, a strongly increased level of VWF is a plausible explanation for this presentation, as VWF is known to sustainin vitroformation of clots, even with inhibited platelets.30Detecting this type of mismatch may be clinically relevant because this mechanism may occurin vivoas well, as we have observed in a patient with clopidogrel treatment failure.31On the contrary, thrombocytosis appears to induce permeable curves despite high VASP-PRI values demonstrating HPR.